QuickView for Plagl1 (gene)
- Gene Symbol:
- PLAGL1
Homo sapiens - Full name:
- PLAG1 like zinc finger 1
- Synonyms:
- LOT1, ZAC, ZAC1, zinc finger protein PLAGL1, PLAG-like 1, lost on transformation 1, pleiomorphic adenoma gene-like 1, tumor suppressor ZAC
- Genomic Location:
- Chr 6: 144303130-144427428
- Description:
-
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of a...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
6q24.2
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | intracellular signal transduction | regulation of cell cycle G1/S phase transition | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | positive regulation of cellular biosynthetic process | cellular process | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell cycle phase transition | programmed cell death | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | apoptotic process | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | cellular response to DNA damage stimulus | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | signal transduction involved in cell cycle checkpoint | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | G1 DNA damage checkpoint | cell cycle arrest | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | gene expression | signal transduction involved in mitotic cell cycle checkpoint | transcription, DNA-templated | negative regulation of cell cycle | negative regulation of cell cycle G1/S phase transition | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | signal transduction involved in DNA damage checkpoint | positive regulation of cell cycle process | mitotic G1/S transition checkpoint | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | signal transduction | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | Golgi apparatus | endomembrane system | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
