QuickView for Platelet-derived growth factor receptor beta (biogroup)

Description:: Platelet-derived growth factor (PDGF) is a growth factor that plays a significant role in cell proliferation and embryonic develpment. It is regulated through the platelet-derived growth factor receptor (PDGFR), a tyrosine kinase (RTK). There are two types of PDGFR: alpha and beta. This entry represents the beta type PDGFR (PGFRB). In human, there are four genes expressing PDGF chains: PDGF-A, B, C and D. They can form isoforms with each other, such as PDGF-AA, AB, BB, CC and DD. PDGF isoforms bind twodistinct receptors, PDGF-alpha and -beta, and this mechanism induces receptor autophosphorylation and activates signal transduction. PDGFR beta acts as a receptor for homodimeric PDGF-BB and PDGF-DD and for heterodimers formed by PDGF-AB.The activities of the PDGFs have been extensively studied at the molecular and cellular level and in in vivo model systems. The chromosomal aberrations involving PGFRB have been linked to several human cancers. PDGF beta is a potential target in tumor treatment.

1 feature

Symbol	EntrezGene ID
PDGFRB	5159