QuickView for Plk3 (gene)
- Gene Symbol:
- PLK3
Homo sapiens - Full name:
- polo like kinase 3
- Synonyms:
- CNK, FNK, PLK-3, PRK, serine/threonine-protein kinase PLK3, FGF-inducible kinase, cytokine-inducible serine/threonine-protein kinase, proliferation-related kinase
- Genomic Location:
- Chr 1: 45038623-45044254
- Description:
-
The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are i...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1p34.1
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | p53 binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
response to radiation | regulation of cell cycle process | cellular response to decreased oxygen levels | regulation of intracellular protein transport | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | regulation of autophagy | negative regulation of cellular process | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia | positive regulation of protein catabolic process | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | microtubule-based process | cellular process | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | endomembrane system organization | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of chaperone-mediated autophagy | regulation of metabolic process | positive regulation of cellular protein metabolic process | positive regulation of chaperone-mediated autophagy | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | Golgi inheritance | regulation of cell division | positive regulation of cellular protein catabolic process | response to stimulus | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | cellular response to hypoxia | response to stress | positive regulation of cellular protein localization | regulation of cell cycle phase transition | protein serine/threonine kinase activity | programmed cell death | supramolecular fiber organization | positive regulation of proteolysis involved in cellular protein catabolic process | positive regulation of proteolysis | cell cycle G1/S phase transition | regulation of protein transport | negative regulation of metabolic process | protein modification process | regulation of peptide transport | macromolecule modification | regulation of intracellular transport | regulation of nucleic acid-templated transcription | apoptotic process | protein kinase B signaling | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | phosphorus metabolic process | cellular response to DNA damage stimulus | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | positive regulation of intracellular protein transport | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | endomitotic cell cycle | response to oxidative stress | Golgi disassembly | response to osmotic stress | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | G2/M transition of mitotic cell cycle | phosphorylation | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | regulation of cytokinesis | cytoplasmic microtubule organization | regulation of protein metabolic process | cell cycle G2/M phase transition | G1/S transition of mitotic cell cycle | positive regulation of establishment of protein localization | regulation of RNA metabolic process | positive regulation of transport | regulation of mitotic cell cycle | organelle disassembly | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of cell cycle arrest | protein metabolic process | regulation of establishment of protein localization | G1 DNA damage checkpoint | Golgi organization | regulation of intracellular signal transduction | mitotic cell cycle | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of mitotic cell cycle | protein kinase activity | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | response to reactive oxygen species | signal transduction involved in mitotic cell cycle checkpoint | cytoskeleton organization | positive regulation of autophagy | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | signaling | regulation of transcription, DNA-templated | cellular protein metabolic process | signal transduction involved in DNA damage checkpoint | kinase activity | organelle inheritance | organelle organization | positive regulation of cell cycle process | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | regulation of transport | cell cycle phase transition | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of protein localization | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | signal transduction | regulation of signaling | macromolecule metabolic process
GO Cellular Component
Golgi stack | dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | microtubule organizing center | cell body | cell | nuclear lumen | neuronal cell body | nucleolus | cytoplasm | intracellular organelle | dendritic tree | centrosome | Golgi apparatus | cell projection | endomembrane system | nucleoplasm | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | intracellular
