QuickView for Plzf (gene)
- Gene Symbol:
- ZBTB16
Homo sapiens - Full name:
- zinc finger and BTB domain containing 16
- Synonyms:
- PLZF, ZNF145, zinc finger and BTB domain-containing protein 16, promyelocytic leukaemia zinc finger, zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia), zinc finger protein PLZF
- Genomic Location:
- Chr 11: 113435641-113626608
- Description:
-
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberran...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
11q23.2
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | enhancer binding | cation binding | nucleic acid binding | protein domain specific binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | double-stranded DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | metal ion binding | heterocyclic compound binding | protein C-terminus binding
GO Biological Process
RNA metabolic process | limb development | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | developmental process involved in reproduction | positive regulation of apoptotic process | regulation of programmed cell death | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | male gamete generation | nervous system development | positive regulation of cell adhesion | positive regulation of T cell differentiation | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of cartilage development | localization | limb morphogenesis | immune system development | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | positive regulation of chondrocyte differentiation | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | hindlimb morphogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | urogenital system development | embryonic limb morphogenesis | positive regulation of immune system process | germ cell development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of cell-cell adhesion | protein localization to nucleus | programmed cell death | male germ-line stem cell asymmetric division | positive regulation of cell activation | reproduction | cellular localization | cellular nitrogen compound metabolic process | positive regulation of T cell activation | germ-line stem cell division | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | negative regulation of hemopoiesis | protein modification process | cartilage development | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | macromolecule modification | regulation of lymphocyte differentiation | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | apoptotic process | system development | positive regulation of NK T cell differentiation | nitrogen compound metabolic process | reproductive process | regulation of cartilage development | multicellular organism development | positive regulation of lymphocyte differentiation | regulation of ossification | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | forelimb morphogenesis | stem cell division | positive regulation of cellular metabolic process | regulation of lymphocyte activation | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | protein localization to organelle | positive regulation of cell differentiation | biosynthetic process | cell division | aromatic compound biosynthetic process | positive regulation of ossification | mesonephros development | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | asymmetric cell division | regulation of RNA metabolic process | renal system development | embryonic hindlimb morphogenesis | embryonic morphogenesis | multicellular organism reproduction | protein metabolic process | DNA-binding transcription factor activity | regionalization | protein ubiquitination | regulation of hemopoiesis | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | cellular protein localization | positive regulation of cell death | regulation of chondrocyte differentiation | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | regulation of cell activation | positive regulation of programmed cell death | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | protein modification by small protein conjugation or removal | transcription, DNA-templated | regulation of NK T cell differentiation | regulation of transcription, DNA-templated | cell development | embryonic digit morphogenesis | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | protein localization | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of fat cell differentiation | regulation of developmental process | developmental process | positive regulation of alpha-beta T cell activation | spermatogenesis | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | asymmetric stem cell division | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of cell death | sexual reproduction | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | positive regulation of gene expression | post-translational protein modification | embryonic pattern specification | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | PML body | nucleoplasm | plasma membrane | nuclear speck | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
