QuickView for PpL (gene)

Gene Symbol:

PPL Homo sapiens

Full name:

periplakin

Synonyms:

periplakin, 190 kDa paraneoplastic pemphigus antigen, 195 kDa cornified envelope precursor protein

Genomic Location:

Chr 16: 4872509-4927137

Description:

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a l...

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The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

P53_DECAMER_Q2 ,  TTGCWCAAY_CEBPB_02 ,  GATA_C ,  CEBP_Q2_01 ,  CEBPB_01 ,  P53_02 ,  CEBPB_02 ,  HIF1_Q5 ,  RNGTGGGC_UNKNOWN ,  HLF_01 ,  CHOP_01 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

16p13.3

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