QuickView for Psme2 (gene)

Gene Symbol:

PSME2 Homo sapiens

Full name:

proteasome activator subunit 2

Synonyms:

PA28B, PA28beta, REGbeta, proteasome activator complex subunit 2, 11S regulator complex beta subunit, 11S regulator complex subunit beta, MCP activator, 31-kD subunit, REG-beta, activator of multicatalytic protease subunit 2, cell migration-inducing protein 22, proteasome (prosome, macropain) activator subunit 2 (PA28 beta), proteasome activator 28 subunit beta, proteasome activator 28-beta, proteasome activator hPA28 subunit beta

Genomic Location:

Chr 14: 23682414-23685695

Description:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which cont...

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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  IRF1_Q6 ,  P53_02 ,  AR_01 ,  AR_Q2 ,  CETS1P54_01 ,  ETS1_B ,  ELF1_Q6 ,  STTTCRNTTT_IRF_Q6

Cytogenetic Map:

14q12

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