QuickView for Ptpn14 (gene)

Gene Symbol:

PTPN14 Homo sapiens

Full name:

protein tyrosine phosphatase, non-receptor type 14

Synonyms:

CATLPH, PEZ, PTP36, tyrosine-protein phosphatase non-receptor type 14, cytoskeletal-associated protein tyrosine phosphatase, protein-tyrosine phosphatase pez

Genomic Location:

Chr 1: 212597634-212791265

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 sup...

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ZIC3_01 ,  CTGCAGY_UNKNOWN

Cytogenetic Map:

1q32.3-q41

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