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QuickView for Pyrimethamine (compound)
PubChem
| Name: | Pyrimethamine |
|---|---|
| PubChem Compound ID: | 4993 |
| Description: | One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. |
| Molecular formula: | C12H13ClN4 |
| Molecular weight: | 248.711 g/mol |
| Synonyms: |
Diaminopyritamin; NSC-3061; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; Pyremethamine; Malacid; NCI60_002604; Daraprim; 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-; KBioGR_001007; Darapram.
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DrugBank
Identification
| Name: | Pyrimethamine |
|---|---|
| Name (isomeric): | DB00205 |
| Drug Type: | small molecule |
| Description: | One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. |
| Synonyms: |
Diaminopyritamin; Pirimetamin; Ethylpyrimidine; CD; Pyrimethamine Hcl; Pyremethamine; Primethamine; Pirimetamina; Chloridine; Pyrimethamin.
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| Brand: | Tindurin, Darapram, Daraprim, Tinduring, Maloprim, Pirimecidan, Daraclor, Darachlor, Fansidar, Erbaprelina, Khloridin, Malocide, Malocid, Daraprime, Disulone, Malacid |
| Brand name mixture: | Quinnoxine-S(Pyrimethamine + Sulfaquinoxaline), Fansidar Tablets(Pyrimethamine + Sulfadoxine), Sulfaquinoxaline-S Liq(Pyrimethamine + Sulfaquinoxaline) |
| Category: | Antimalarials, Antiprotozoal Agents, Antiprotozoals, Folic Acid Antagonists |
| CAS number: | 58-14-0 |
Pharmacology
| Indication: | For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine |
|---|---|
| Pharmacology: |
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growt...
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| Mechanism of Action: | Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver. |
| Absorption: | Well absorbed with peak levels occurring between 2 to 6 hours following administration |
| Protein binding: | 87% |
| Biotransformation: | Hepatic |
| Half Life: | 96 hours |
| Affected organisms: | Plasmodium |
Interactions
| Food interaction: |
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Targets
Enzymes
