QuickView for Qa-1 (gene)

Gene Symbol:

HLA-B Homo sapiens

Full name:

major histocompatibility complex, class I, B

Synonyms:

AS, B-4901, HLAB, major histocompatibility complex, class I, B, HLA class I antigen HLA-B, HLA class I histocompatibility antigen, B alpha chain, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, MHC class 1 antigen, MHC class I antigen HLA-B alpha chain, MHC class I antigen HLA-B heavy chain, MHC class I antigen SHCHA, MHC class I molecule, leukocyte antigen class I-B

Genomic Location:

Chr 6: 31429628-31432914

Description:

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are ex...

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HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RGAANNTTC_HSF1_01 ,  CTTTAAR_UNKNOWN ,  HSF2_01

Cytogenetic Map:

6p21.33

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