QuickView for RAN;jsessionid=14068BBD14E9F85F0CC01BA459702EFC (gene)

Gene Symbol:

RAN Homo sapiens

Full name:

RAN, member RAS oncogene family

Synonyms:

ARA24, Gsp1, TC4, GTP-binding nuclear protein Ran, GTPase Ran, OK/SW-cl.81, RanGTPase, androgen receptor-associated protein 24, guanosine triphosphatase Ran, member RAS oncogene family, ras-like protein TC4, ras-related nuclear protein

Genomic Location:

Chr 12: 129922521-129927316

Description:

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chr...

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RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGATGC_MIR3245P ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGANNYRGCA_TCF11MAFG_01 ,  CCTGTGA_MIR513 ,  NRF2_Q4 ,  AGTCTAG_MIR151 ,  TCF11_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-151

Cytogenetic Map:

12q24.33

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