QuickView for RARB (gene)

Gene Symbol:

RARB Homo sapiens

Full name:

retinoic acid receptor beta

Synonyms:

HAP, MCOPS12, NR1B2, RARbeta1, RRB2, retinoic acid receptor beta, HBV-activated protein, RAR-beta, RAR-epsilon, hepatitis B virus activated protein, nuclear receptor subfamily 1 group B member 2, retinoic acid receptor, beta polypeptide

Genomic Location:

Chr 3: 25444758-25614424

Description:

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, c...

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This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PBX1_02 ,  OCT1_07 ,  OCT1_05 ,  CEBPA_01 ,  HNF1_01 ,  AGTTCTC_MIR146A_MIR146B ,  AAGCCAT_MIR135A_MIR135B ,  TCANNTGAY_SREBP1_01 ,  FOXJ2_02 ,  P53_DECAMER_Q2 ,  VDR_Q3 ,  ATGTCAC_MIR489 ,  YATGNWAAT_OCT_C ,  POU3F2_01 ,  GATA_C ,  SRF_Q6 ,  SMAD3_Q6 ,  CEBP_Q2_01 ,  YATTNATC_UNKNOWN ,  VDR_Q6 ,  CAGTGTT_MIR141_MIR200A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  STAT6_01 ,  E2F_01 ,  CTTTGA_LEF1_Q2 ,  PBX1_01 ,  MAF_Q6 ,  OCT1_Q5_01 ,  GATA1_04 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  STAT_Q6 ,  HNF4_01 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  CEBPB_01 ,  CACCCBINDINGFACTOR_Q6 ,  ACATTCC_MIR1_MIR206 ,  GGGYGTGNY_UNKNOWN ,  CATTTCA_MIR203 ,  FOXO3_01 ,  GGATTA_PITX2_Q2 ,  P53_02 ,  LHX3_01 ,  HNF4_Q6 ,  NF1_Q6 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  STAT5A_03 ,  SRF_Q4 ,  NKX61_01 ,  MGGAAGTG_GABP_B ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TGCCAAR_NF1_Q6 ,  NF1_Q6_01 ,  SOX5_01 ,  ATACTGT_MIR144 ,  PAX8_B ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  AR_Q2 ,  GFI1_01 ,  EN1_01 ,  CEBP_Q3 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  MSX1_01 ,  GATA1_05 ,  IK1_01 ,  SRF_Q5_01 ,  AAGCACT_MIR520F ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  YWATTWNNRGCT_UNKNOWN ,  FOXM1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ACCTGTTG_UNKNOWN ,  PAX2_02 ,  CCAWWNAAGG_SRF_Q4 ,  HNF1_Q6 ,  RYTAAWNNNTGAY_UNKNOWN ,  HNF4_01_B ,  FOXO4_02 ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-376c

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Cytogenetic Map:

3p24.2

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