QuickView for RBBP8 (gene)

Gene Symbol:

RBBP8 Homo sapiens

Full name:

RB binding protein 8, endonuclease

Synonyms:

COM1, CTIP, JWDS, RIM, SAE2, SCKL2, DNA endonuclease RBBP8, CTBP-interacting protein, RBBP-8, retinoblastoma binding protein 8, sporulation in the absence of SPO11 protein 2 homolog

Genomic Location:

Chr 18: 18767293-18860447

Description:

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transc...

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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  TTTGCAC_MIR19A_MIR19B ,  ATF4_Q2 ,  ACTTTAT_MIR1425P ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CREB_Q4 ,  CREBP1_Q2 ,  GTGACGY_E4F1_Q6 ,  CREB_02 ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  NKX61_01 ,  NRF1_Q6 ,  YCATTAA_UNKNOWN ,  CREB_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  GGCKCATGS_UNKNOWN ,  RRCCGTTA_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-19

Cytogenetic Map:

18q11.2

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