QuickView for RC3H1;jsessionid=3330AAACC1084E8D3675E281A0323905 (gene)
- Gene Symbol:
- RC3H1
Homo sapiens - Full name:
- ring finger and CCCH-type domains 1
- Synonyms:
- RNF198, ROQUIN, roquin-1, RING finger and C3H zinc finger protein 1, RING finger and CCCH-type zinc finger domain-containing protein 1, RING finger protein 198, probable E3 ubiquitin-protein ligase Roquin
- Genomic Location:
- Chr 1: 172166975-172228833
- Description:
-
This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1q25.1
GO Molecular Function
RNA stem-loop binding | cation binding | nucleic acid binding | mRNA binding | catalytic activity | ubiquitin-like protein transferase activity | miRNA binding | ubiquitin protein ligase activity | ion binding | organic cyclic compound binding | protein binding | zinc ion binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | ubiquitin-like protein ligase activity | mRNA 3'-UTR binding | metal ion binding | heterocyclic compound binding | RNA binding | double-stranded RNA binding
GO Biological Process
positive regulation of immune response | negative regulation of lymphocyte differentiation | RNA metabolic process | leukocyte homeostasis | negative regulation of leukocyte activation | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | response to cytokine | response to interleukin-1 | regulation of B cell activation | CD4-positive, alpha-beta T cell activation | negative regulation of activated T cell proliferation | immune response-regulating signaling pathway | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | regulation of T-helper 17 type immune response | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | negative regulation of B cell proliferation | cellular process | organic substance catabolic process | lymphocyte differentiation | negative regulation of germinal center formation | immune system development | negative regulation of alpha-beta T cell differentiation | negative regulation of T-helper 17 cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | negative regulation of cellular metabolic process | regulation of T cell receptor signaling pathway | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | positive regulation of mRNA catabolic process | regulation of mRNA stability | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | catabolic process | T cell differentiation involved in immune response | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | mRNA catabolic process | T cell activation | response to stimulus | positive regulation of NIK/NF-kappaB signaling | alpha-beta T cell activation involved in immune response | positive regulation of immune system process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | mononuclear cell proliferation | negative regulation of lymphocyte activation | leukocyte activation involved in immune response | posttranscriptional regulation of gene expression | regulation of cell proliferation | cellular nitrogen compound metabolic process | immune response-activating signal transduction | negative regulation of metabolic process | hemopoiesis | cellular component assembly | negative regulation of hemopoiesis | protein modification process | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | regulation of cell adhesion | macromolecule modification | nucleobase-containing compound catabolic process | regulation of lymphocyte differentiation | negative regulation of adaptive immune response | T-helper cell differentiation | leukocyte differentiation | organelle assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of T-helper cell differentiation | 3'-UTR-mediated mRNA destabilization | multicellular organism development | spleen development | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of miRNA metabolic process | regulation of T cell activation | regulation of activated T cell proliferation | regulation of gene expression | negative regulation of T-helper 17 type immune response | RNA catabolic process | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of germinal center formation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of T cell activation | positive regulation of intracellular signal transduction | regulation of RNA stability | alpha-beta T cell differentiation | ubiquitin protein ligase activity | regulation of T-helper 17 cell differentiation | B cell homeostasis | homeostasis of number of cells | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | regulation of cellular protein metabolic process | negative regulation of immune response | T cell activation involved in immune response | cellular protein-containing complex assembly | negative regulation of cell-cell adhesion | mRNA destabilization | cell communication | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | lymphocyte homeostasis | negative regulation of cell activation | cell activation involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | homeostatic process | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of RNA metabolic process | negative regulation of T cell differentiation | negative regulation of B cell activation | lymphocyte activation | protein polyubiquitination | lymph node development | T cell differentiation | protein-containing complex assembly | activation of immune response | protein metabolic process | response to organic substance | protein ubiquitination | regulation of hemopoiesis | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | ubiquitin-protein transferase activity | regulation of adaptive immune response | negative regulation of leukocyte proliferation | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | regulation of mRNA catabolic process | negative regulation of cellular protein metabolic process | T cell proliferation | regulation of cell activation | ribonucleoprotein complex assembly | alpha-beta T cell activation | protein modification by small protein conjugation or removal | RNA destabilization | cytoplasmic mRNA processing body assembly | antigen receptor-mediated signaling pathway | negative regulation of translation | T cell homeostasis | cell activation | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | lymphocyte proliferation | regulation of cell communication | signaling | regulation of T cell proliferation | cellular protein metabolic process | T follicular helper cell differentiation | regulation of developmental process | developmental process | organelle organization | cellular response to interleukin-1 | cellular protein modification process | negative regulation of alpha-beta T cell activation | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | heterocycle metabolic process | positive regulation of metabolic process | ribonucleoprotein complex biogenesis | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of translation | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | negative regulation of cell differentiation | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
cytoplasmic stress granule | cell | ribonucleoprotein granule | cytoplasm | intracellular organelle | P-body | protein-containing complex | ribonucleoprotein complex | organelle | cytoplasmic ribonucleoprotein granule | intracellular
