QuickView for RFC2;jsessionid=539031157B7BC1F17B190246350ACFE2 (gene)

Gene Symbol:

RFC2 Homo sapiens

Full name:

replication factor C subunit 2

Synonyms:

RFC40, replication factor C subunit 2, A1 40 kDa subunit, RF-C 40 kDa subunit, activator 1 subunit 2, replication factor C (activator 1) 2, 40kDa

Genomic Location:

Chr 7: 73283768-73306674

Description:

This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of fiv...

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This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SCGGAAGY_ELK1_02

Cytogenetic Map:

7q11.23

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