QuickView for RGR;jsessionid=8C7ED266B4A6EE19B1EB123AD40592D0 (gene)

Gene Symbol:

RGR Homo sapiens

Full name:

retinal G protein coupled receptor

Synonyms:

RP44, RPE-retinal G protein-coupled receptor, RGR-opsin

Genomic Location:

Chr 10: 85994789-86008924

Description:

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the convers...

View Full Description

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBP_Q2_01 ,  GGATTA_PITX2_Q2 ,  CEBPB_02 ,  HLF_01 ,  CAGCTG_AP4_Q5 ,  LBP1_Q6

Cytogenetic Map:

10q23.1

search → result