QuickView for RGS14 (gene)

Gene Symbol:

RGS14 Homo sapiens

Full name:

regulator of G protein signaling 14

Synonyms:

regulator of G-protein signaling 14, regulator of G-protein signalling 14

Genomic Location:

Chr 5: 176717450-176732205

Description:

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GT...

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This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ETS_Q4 ,  ZIC1_01 ,  RYTTCCTG_ETS2_B ,  TEL2_Q6 ,  OSF2_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  MGGAAGTG_GABP_B ,  RACCACAR_AML_Q6 ,  RNGTGGGC_UNKNOWN ,  CETS1P54_01 ,  P300_01 ,  GGCAGTG_MIR3243P ,  ETS1_B ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-324-3p

Cytogenetic Map:

5q35.3

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