QuickView for RHOC;jsessionid=6ED720D4FDACA69214345966FD2F9083 (gene)

Gene Symbol:

RHOC Homo sapiens

Full name:

ras homolog family member C

Synonyms:

ARH9, ARHC, H9, RHOH9, rho-related GTP-binding protein RhoC, RAS-related homolog 9, oncogene RHO H9, ras homolog gene family, member C, rho cDNA clone 9, rhoC GTPase, small GTP binding protein RhoC

Genomic Location:

Chr 1: 113045272-113051548

Description:

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is pre...

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This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CAGCACT_MIR5123P ,  ACTTTAT_MIR1425P ,  RYCACNNRNNRNCAG_UNKNOWN ,  MYB_Q5_01 ,  GGGAGGRR_MAZ_Q6 ,  CACCAGC_MIR138 ,  BACH2_01 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  MYB_Q6 ,  YTAAYNGCT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-93

Cytogenetic Map:

1p13.2

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