QuickView for RIPK3 (gene)
- Gene Symbol:
- RIPK3
Homo sapiens - Full name:
- receptor interacting serine/threonine kinase 3
- Synonyms:
- RIP3, receptor-interacting serine/threonine-protein kinase 3, RIP-3, RIP-like protein kinase 3, receptor interacting protein 3
- Genomic Location:
- Chr 14: 23875067-23879082
- Description:
-
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and exp...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
14q12
GO Molecular Function
protein-containing complex binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | transcription coactivator activity | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | transcription coregulator activity | NF-kappaB-inducing kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
leukocyte homeostasis | regulation of T cell mediated immunity | protein homooligomerization | positive regulation of macromolecule biosynthetic process | regulation of dephosphorylation | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | necroptotic process | regulation of immune system process | regulation of phosphatase activity | cell differentiation | regulation of T cell mediated cytotoxicity | positive regulation of intrinsic apoptotic signaling pathway | positive regulation of ligase activity | regulation of leukocyte mediated cytotoxicity | positive regulation of phosphate metabolic process | positive regulation of dephosphorylation | regulation of necroptotic process | positive regulation of cellular biosynthetic process | cellular process | regulation of necrotic cell death | lymphocyte differentiation | regulation of cell motility | positive regulation of reactive oxygen species metabolic process | programmed necrotic cell death | immune system development | positive regulation of protein kinase activity | positive regulation of necrotic cell death | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of lymphocyte apoptotic process | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | regulation of cellular extravasation | positive regulation of cellular protein metabolic process | cellular component organization | T cell activation | response to stimulus | thymus development | positive regulation of protein metabolic process | regulation of cell proliferation | protein serine/threonine kinase activity | programmed cell death | positive regulation of phosphatase activity | supramolecular fiber organization | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | macromolecule modification | activation of protein kinase activity | molecular function regulator | regulation of nucleic acid-templated transcription | leukocyte differentiation | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of necroptotic process | multicellular organism development | phosphorus metabolic process | protein complex oligomerization | spleen development | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | amyloid fibril formation | regulation of T cell activation | regulation of activated T cell proliferation | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | regulation of cellular component movement | positive regulation of hydrolase activity | homeostasis of number of cells | regulation of cellular protein metabolic process | phosphorylation | regulation of apoptotic signaling pathway | protein phosphorylation | regulation of leukocyte migration | phosphate-containing compound metabolic process | regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | lymphocyte homeostasis | regulation of T cell apoptotic process | regulation of T cell migration | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | regulation of locomotion | transcription coactivator activity | regulation of RNA metabolic process | apoptotic signaling pathway | lymphocyte activation | positive regulation of molecular function | lymph node development | T cell differentiation | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | gland development | T cell differentiation in thymus | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | metabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of cell death | protein kinase activity | organic substance metabolic process | cell death | animal organ development | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | T cell homeostasis | cell activation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of T cell proliferation | I-kappaB kinase/NF-kappaB signaling | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | protein heterooligomerization | kinase activity | developmental process | cellular protein modification process | regulation of reactive oxygen species metabolic process | necrotic cell death | regulation of activation-induced cell death of T cells | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | NF-kappaB-inducing kinase activity | NIK/NF-kappaB signaling | positive regulation of metabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of cell death | regulation of lymphocyte migration | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | mitochondrion | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular | membrane
