QuickView for RNF125 (gene)

Gene Symbol:

RNF125 Homo sapiens

Full name:

ring finger protein 125

Synonyms:

TNORS, TRAC-1, TRAC1, E3 ubiquitin-protein ligase RNF125, T-cell RING activation protein 1, T-cell ring protein identified in activation screen, ring finger protein 125, E3 ubiquitin protein ligase

Genomic Location:

Chr 18: 27852443-27907152

Description:

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a pos...

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This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ZF5_01 ,  MYCMAX_B ,  GCTTGAA_MIR498 ,  ATGCTGC_MIR103_MIR107 ,  ZF5_B ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GGGTGGRR_PAX4_03

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-15

Cytogenetic Map:

18q12.1

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