QuickView for RNF8;jsessionid=CE4DE7BD345B7A43845A02C656C701D4 (gene)

Gene Symbol:

RNF8 Homo sapiens

Full name:

ring finger protein 8

Synonyms:

hRNF8, E3 ubiquitin-protein ligase RNF8, C3HC4-type zinc finger protein, RING-type E3 ubiquitin transferase RNF8, UBC13/UEV-interacting ring finger protein, ring finger protein (C3HC4 type) 8, ring finger protein 8, E3 ubiquitin protein ligase

Genomic Location:

Chr 6: 37429726-37470492

Description:

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a...

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The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Danio rerio ,  Gallus gallus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGCGGR_SP1_Q6 ,  RCGCANGCGY_NRF1_Q6

Cytogenetic Map:

6p21.2

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