QuickView for ROBO2;jsessionid=A9FD2E14C93241A69C566CE43001DB3E (gene)

Gene Symbol:

ROBO2 Homo sapiens

Full name:

roundabout guidance receptor 2

Synonyms:

SAX3, roundabout homolog 2, roundabout, axon guidance receptor, homolog 2

Genomic Location:

Chr 3: 77171984-77779351

Description:

The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflu...

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The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CTATGCA_MIR153 ,  GTACTGT_MIR101 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  ATAGGAA_MIR202 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  GTCAGGA_MIR378 ,  AAAGACA_MIR511 ,  AATGTGA_MIR23A_MIR23B ,  AAAGGAT_MIR501 ,  GTTAAAG_MIR302B ,  CCACACA_MIR147 ,  AAGCACA_MIR218

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Cytogenetic Map:

3p12.3

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