QuickView for RORC;jsessionid=8D2E56A423157A2C98F684734E184B55 (gene)
- Gene Symbol:
- RORC
Homo sapiens - Full name:
- RAR related orphan receptor C
- Synonyms:
- IMD42, NR1F3, RORG, RZR-GAMMA, RZRG, TOR, nuclear receptor ROR-gamma, RAR-related orphan nuclear receptor variant 2, RAR-related orphan receptor C, nuclear receptor RZR-gamma, nuclear receptor subfamily 1 group F member 3, retinoic acid-binding receptor gamma, retinoid-related orphan receptor gamma
- Genomic Location:
- Chr 1: 150045171-150070972
- Description:
-
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1q21.3
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | lipid binding | sterol binding | transcription coactivator binding | steroid hormone receptor activity | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion binding | organic cyclic compound binding | oxysterol binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | steroid binding | transcription cofactor binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | adipose tissue development | DNA-templated transcription, initiation | adaptive immune response | positive regulation of circadian rhythm | positive regulation of macromolecule biosynthetic process | CD4-positive, alpha-beta T cell differentiation | response to cytokine | CD4-positive, alpha-beta T cell activation | regulation of carbohydrate metabolic process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | lymphocyte differentiation | T-helper 17 cell differentiation | nuclear receptor activity | circadian regulation of gene expression | immune system development | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | xenobiotic metabolic process | T cell differentiation involved in immune response | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | T cell activation | response to stimulus | alpha-beta T cell activation involved in immune response | cellular response to xenobiotic stimulus | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | circadian rhythm | rhythmic process | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | regulation of steroid metabolic process | regulation of nucleic acid-templated transcription | T-helper cell differentiation | leukocyte differentiation | cellular response to hormone stimulus | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | cellular response to sterol | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | cellular response to cytokine stimulus | biosynthetic process | aromatic compound biosynthetic process | T cell activation involved in immune response | response to xenobiotic stimulus | cell communication | regulation of cellular metabolic process | cell activation involved in immune response | regulation of RNA metabolic process | lymphocyte activation | T cell differentiation | DNA-binding transcription factor activity | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | alpha-beta T cell activation | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | regulation of transcription involved in cell fate commitment | transcription, DNA-templated | cell activation | intracellular receptor signaling pathway | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular macromolecule biosynthetic process | regulation of circadian rhythm | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | response to steroid hormone | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nuclear body | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
