QuickView for RPA2;jsessionid=47D9CB26C55CE2A95B826840B32C8022 (gene)

Gene Symbol:

RPA2 Homo sapiens

Full name:

replication protein A2

Synonyms:

REPA2, RP-A p32, RP-A p34, RPA32, replication protein A 32 kDa subunit, RF-A protein 2, replication factor A protein 2, replication protein A 34 kDa subunit

Genomic Location:

Chr 1: 28090636-28113823

Description:

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage throu...

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This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFMUE1_Q6 ,  NFY_C ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  E2F1_Q4 ,  OSF2_Q6 ,  LEF1_Q2 ,  NFY_Q6_01 ,  LHX3_01 ,  MGGAAGTG_GABP_B ,  E2F_03 ,  OCT1_06 ,  TAATTA_CHX10_01 ,  YTAATTAA_LHX3_01 ,  CDC5_01 ,  TGACATY_UNKNOWN

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Cytogenetic Map:

1p35.3

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