QuickView for RPL7 (gene)

Gene Symbol:

RPL7 Homo sapiens

Full name:

ribosomal protein L7

Synonyms:

L7, humL7-1, 60S ribosomal protein L7, large ribosomal subunit protein uL30

Genomic Location:

Chr 8: 74365428-74368423

Description:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosoma...

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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACWWCAANK_UNKNOWN ,  SP1_01 ,  TCCCRNNRTGC_UNKNOWN ,  RRAGTTGT_UNKNOWN ,  ACTAYRNNNCCCR_UNKNOWN ,  CTTTAAR_UNKNOWN ,  SP1_Q6 ,  WCAANNNYCAG_UNKNOWN ,  RCGCANGCGY_NRF1_Q6 ,  SMAD_Q6 ,  GGCKCATGS_UNKNOWN

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Cytogenetic Map:

8q21.11

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