QuickView for RPS19 (gene)

Gene Symbol:

RPS19 Homo sapiens

Full name:

ribosomal protein S19

Synonyms:

DBA, DBA1, S19, 40S ribosomal protein S19, small ribosomal subunit protein eS19

Genomic Location:

Chr 19: 47055828-47067324

Description:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosoma...

View Full Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

P53_DECAMER_Q2 ,  E2F1_Q4_01 ,  CACGTG_MYC_Q2 ,  TMTCGCGANR_UNKNOWN ,  E2F_Q6_01 ,  IRF1_Q6 ,  MYCMAX_B ,  NFKAPPAB65_01 ,  TATAAA_TATA_01 ,  OCT1_Q6 ,  ATGCTGG_MIR338 ,  E2F1_Q6_01 ,  P53_02 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  E2F_Q4_01 ,  RNGTGGGC_UNKNOWN ,  OCT1_02 ,  CEBP_C ,  CART1_01 ,  CREL_01 ,  TBP_01 ,  E2F_Q3_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-338

Cytogenetic Map:

19q13.2

search → result