QuickView for RRM2B;jsessionid=42CC494BDBE760F795E46B43F892952F (gene)

Gene Symbol:

RRM2B Homo sapiens

Full name:

ribonucleotide reductase regulatory TP53 inducible subunit M2B

Synonyms:

MTDPS8A, MTDPS8B, P53R2, ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2 homolog, p53-inducible ribonucleotide reductase small subunit 2 short form beta, p53-inducible ribonucleotide reductase small subunit 2-like protein, ribonucleotide reductase M2 B (TP53 inducible)

Genomic Location:

Chr 8: 103285907-103320522

Description:

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA...

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This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_B ,  WGTTNNNNNAAA_UNKNOWN ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  SREBP1_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  E47_02 ,  RNGTGGGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  CTTTGT_LEF1_Q2

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Cytogenetic Map:

8q22.3

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