RUN domain superfamily QuickView

Description:: The RUN domain, named after RPIP8, unc-14 and NESCA, is organised into sixconserved blocks (A-F), which are predicted to constitute the 'core' of aglobular structure tolerating insertions of considerable length between theconserved blocks. The RUN domain is found in one or two copies in severalproteins that are linked particularly to the functions of GTPases in the Rapand Rab families. RUN domains can be associated with TBC/rab GAP, FYVE, DENN, SH3, DAG/PE-binding, PLAT/LH2, PH or PX domains. The RUN domain may have a role in the interaction of various proteins with cytoskeletal filaments.Structurally, the RUN domain comprises eight anti-parallel alpha-helices, which form an extensive hydrophobic core, followed by an extended segment.

QuickView for RUN domain superfamily (biogroup)