QuickView for Rap1A (gene)

Gene Symbol:

RAP1A Homo sapiens

Full name:

RAP1A, member of RAS oncogene family

Synonyms:

C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21, ras-related protein Rap-1A, GTP-binding protein smg p21A, Ras-related protein Krev-1

Genomic Location:

Chr 1: 111963928-112057624

Description:

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The ...

View Full Description

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TTTTGAG_MIR373 ,  SRF_Q6 ,  CTTTGCA_MIR527 ,  TACTTGA_MIR26A_MIR26B ,  ATCATGA_MIR433 ,  CATTTCA_MIR203 ,  CAGCTTT_MIR320 ,  GAGCCAG_MIR149 ,  CTGAGCC_MIR24 ,  TGCTTTG_MIR330 ,  AAGCACT_MIR520F

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-543

View More

View Less

Cytogenetic Map:

1p13.2

search → result