QuickView for Rasgrp1 (gene)

Gene Symbol:

RASGRP1 Homo sapiens

Full name:

RAS guanyl releasing protein 1

Synonyms:

CALDAG-GEFI, CALDAG-GEFII, RASGRP, V, hRasGRP1, RAS guanyl-releasing protein 1, RAS guanyl nucleotide-releasing protein 1, RAS guanyl releasing protein 1 (calcium and DAG-regulated), calcium and DAG-regulated guanine nucleotide exchange factor II, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II, guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A, ras activator RasGRP

Genomic Location:

Chr 15: 36567596-36644224

Description:

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cell...

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This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  ZF5_B

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-21

Cytogenetic Map:

15q14

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