QuickView for Rasgrp2 (gene)

Gene Symbol:

RASGRP2 Homo sapiens

Full name:

RAS guanyl releasing protein 2

Synonyms:

CALDAG-GEFI, CDC25L, RAS guanyl-releasing protein 2, F25B3.3 kinase-like protein, RAS guanyl nucleotide-releasing protein 2, RAS guanyl releasing protein 2 (calcium and DAG-regulated), calcium and DAG-regulated guanine nucleotide exchange factor I, calcium and diacylglycerol-regulated guanine nucleotide exchange factor I, cdc25-like protein, guanine exchange factor MCG7

Genomic Location:

Chr 11: 64250959-64269504

Description:

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this prot...

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The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MZF1_01 ,  CACGTG_MYC_Q2 ,  CTAWWWATA_RSRFC4_Q2 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  RGAANNTTC_HSF1_01 ,  PAX5_02 ,  TEF1_Q6 ,  LFA1_Q6 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  AP2_Q6_01 ,  SP3_Q3 ,  GGGCGGR_SP1_Q6 ,  TCCAGAT_MIR5165P ,  NF1_Q6_01 ,  HSF2_01 ,  AP2_Q6 ,  WGGAATGY_TEF1_Q6 ,  YY1_02 ,  USF2_Q6 ,  P300_01 ,  MZF1_02 ,  ERR1_Q2 ,  DR4_Q2 ,  CP2_01 ,  GGGTGGRR_PAX4_03 ,  SF1_Q6

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Cytogenetic Map:

11q13.1

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