QuickView for Rassf1 (gene)

Gene Symbol:

RASSF1 Homo sapiens

Full name:

Ras association domain family member 1

Synonyms:

123F2, NORE2A, RASSF1A, RDA32, REH3P21, ras association domain-containing protein 1, Ras association (RalGDS/AF-6) domain family member 1, WUGSC:H_LUCA12.5, cardiac-specific ras association domain family 1 protein, pancreas-specific ras association domain family 1 protein, tumor suppressor protein RDA32

Genomic Location:

Chr 3: 50342221-50353371

Description:

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. ...

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This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  CCCAGAG_MIR326 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGACCTY_ERR1_Q2 ,  GTGTGAG_MIR342 ,  GGGCGGR_SP1_Q6 ,  GACAGGG_MIR339 ,  CP2_02 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-342

Cytogenetic Map:

3p21.31

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