QuickView for Rev1 (gene)

Gene Symbol:

REV1 Homo sapiens

Full name:

REV1, DNA directed polymerase

Synonyms:

AIBP80, REV1L, DNA repair protein REV1, REV1 homolog, REV1, polymerase (DNA directed), REV1- like, alpha integrin-binding protein 80, rev1-like terminal deoxycytidyl transferase

Genomic Location:

Chr 2: 99383370-99472912

Description:

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA.

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACGTG_MYC_Q2 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ARNT_02 ,  PBX1_01 ,  GTACAGG_MIR486 ,  CATGTAA_MIR496 ,  GTTTGTT_MIR495 ,  GGGCGGR_SP1_Q6 ,  GTGCCAA_MIR96 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  ACAWYAAAG_UNKNOWN ,  HIF1_Q3

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Cytogenetic Map:

2q11.2

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