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QuickView for Rev1 (gene)

Gene Symbol:
REV1 Homo sapiens Homo sapiens
Full name:
REV1, DNA directed polymerase
AIBP80, REV1L, DNA repair protein REV1, REV1 homolog, REV1, polymerase (DNA directed), REV1- like, alpha integrin-binding protein 80, rev1-like terminal deoxycytidyl transferase
Genomic Location:
Chr 2: 99383370-99472912
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA.
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2

GO Molecular Function

cation binding | nucleic acid binding | nucleotidyltransferase activity | catalytic activity | DNA binding | damaged DNA binding | ion binding | organic cyclic compound binding | protein binding | transferase activity, transferring phosphorus-containing groups | transferase activity | deoxycytidyl transferase activity | metal ion binding | heterocyclic compound binding

GO Biological Process

response to radiation | translesion synthesis | cellular process | postreplication repair | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to UV | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | DNA repair | response to light stimulus | nitrogen compound metabolic process | cellular response to DNA damage stimulus | DNA biosynthetic process | cellular response to stress | error-prone translesion synthesis | biosynthetic process | aromatic compound biosynthetic process | DNA metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | cellular macromolecule biosynthetic process | DNA synthesis involved in DNA repair | heterocycle metabolic process | cellular metabolic process | DNA replication | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular