QuickView for Rpa1 (gene)

Gene Symbol:

RPA1 Homo sapiens

Full name:

replication protein A1

Synonyms:

HSSB, MST075, REPA1, RF-A, RP-A, RPA70, replication protein A 70 kDa DNA-binding subunit, MSTP075, RF-A protein 1, RP-A p70, replication factor A protein 1, replication protein A1, 70kDa, single-stranded DNA-binding protein

Genomic Location:

Chr 17: 1680095-1748120

Description:

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA da...

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This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ARNT_01 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  TCTGATA_MIR361 ,  GGGCGGR_SP1_Q6 ,  USF_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-361

Cytogenetic Map:

17p13.3

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