QuickView for SAE1 (gene)
- Gene Symbol:
- SAE1
Homo sapiens - Full name:
- SUMO1 activating enzyme subunit 1
- Synonyms:
- AOS1, HSPC140, SUA1, UBLE1A, SUMO-activating enzyme subunit 1, SUMO-1 activating enzyme E1 N subunit, SUMO-1 activating enzyme subunit 1, activator of SUMO1, sentrin/SUMO-activating protein AOS1, ubiquitin-like 1-activating enzyme E1A, ubiquitin-like protein SUMO-1 activating enzyme
- Genomic Location:
- Chr 19: 52325984-52405372
- Description:
-
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19q13.32
GO Molecular Function
enzyme activator activity | SUMO activating enzyme activity | enzyme binding | ATP-dependent protein binding | small protein activating enzyme binding | molecular function regulator | catalytic activity | protein heterodimerization activity | ubiquitin-like modifier activating enzyme activity | protein binding | protein dimerization activity | ligase activity | ubiquitin activating enzyme activity | enzyme regulator activity | protein C-terminus binding
GO Biological Process
regulation of intracellular protein transport | positive regulation of cellular component organization | regulation of cellular localization | enzyme activator activity | regulation of localization | peptidyl-amino acid modification | protein sumoylation | regulation of organelle organization | cellular process | positive regulation of catalytic activity | regulation of cellular process | regulation of cellular protein localization | positive regulation of protein targeting to mitochondrion | positive regulation of cellular protein localization | regulation of protein transport | protein modification process | regulation of peptide transport | macromolecule modification | regulation of intracellular transport | molecular function regulator | positive regulation of mitochondrion organization | nitrogen compound metabolic process | positive regulation of organelle organization | regulation of catalytic activity | positive regulation of intracellular protein transport | protein modification by small protein conjugation | regulation of mitochondrion organization | positive regulation of establishment of protein localization | positive regulation of transport | positive regulation of molecular function | protein metabolic process | regulation of establishment of protein localization | protein ubiquitination | metabolic process | regulation of protein targeting | peptidyl-lysine modification | ubiquitin activating enzyme activity | organic substance metabolic process | protein modification by small protein conjugation or removal | positive regulation of intracellular transport | positive regulation of protein transport | cellular protein metabolic process | enzyme regulator activity | cellular protein modification process | regulation of transport | cellular metabolic process | regulation of protein localization | regulation of cellular component organization | macromolecule metabolic process | regulation of protein targeting to mitochondrion
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | SUMO activating enzyme complex | membrane-enclosed lumen | intracellular
