QuickView for SCKL4 (gene)

Gene Symbol:

PCNT Homo sapiens

Full name:

pericentrin

Synonyms:

KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin, kendrin, pericentrin-2, pericentrin-380, pericentrin-B

Genomic Location:

Chr 21: 46568483-46690110

Description:

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation c...

View Full Description

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFMUE1_Q6 ,  MYB_Q5_01 ,  GCCATNTTG_YY1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  YY1_Q6 ,  LHX3_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  AAGWWRNYGGC_UNKNOWN ,  AHR_Q5 ,  S8_01 ,  NKX25_02 ,  NFY_Q6 ,  NRF1_Q6 ,  GATGKMRGCG_UNKNOWN ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  YY1_02 ,  WTTGKCTG_UNKNOWN ,  YTAATTAA_LHX3_01 ,  TGACAGNY_MEIS1_01 ,  RCGCANGCGY_NRF1_Q6 ,  CTGRYYYNATT_UNKNOWN

View More

View Less

Cytogenetic Map:

21q22.3

search → result