QuickView for SCN11A (gene)

Gene Symbol:

SCN11A Homo sapiens

Full name:

sodium voltage-gated channel alpha subunit 11

Synonyms:

FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2, sodium channel protein type 11 subunit alpha, peripheral nerve sodium channel 5, sensory neuron sodium channel 2, sodium channel protein type XI subunit alpha, sodium channel, voltage-gated, type XI, alpha polypeptide, sodium channel, voltage-gated, type XI, alpha subunit, sodium channel, voltage-gated, type XII, alpha polypeptide, voltage-gated sodium channel subunit alpha Nav1.9

Genomic Location:

Chr 3: 38862264-38967056

Description:

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene fam...

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Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7

Cytogenetic Map:

3p22.2

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