QuickView for SCN1B (gene)

Gene Symbol:

SCN1B Homo sapiens

Full name:

sodium voltage-gated channel beta subunit 1

Synonyms:

ATFB13, BRGDA5, EIEE52, GEFSP1, sodium channel subunit beta-1, sodium channel, voltage gated, type I beta subunit, sodium channel, voltage-gated, type I, beta

Genomic Location:

Chr 19: 40213374-40223193

Description:

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a s...

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Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAL1ALPHAE47_01 ,  TAL1BETAE47_01 ,  CACCAGC_MIR138 ,  TAL1BETAITF2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-433-3p

Cytogenetic Map:

19q13.11

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