QuickView for SCN4A (gene)

Gene Symbol:

SCN4A Homo sapiens

Full name:

sodium voltage-gated channel alpha subunit 4

Synonyms:

CMS16, HOKPP2, HYKPP, HYPP, NAC1A, Na(V)1.4, Nav1.4, SkM1, sodium channel protein type 4 subunit alpha, CTC-264K15.6, skeletal muscle sodium channel alpha subunit, skeletal muscle voltage-dependent sodium channel type IV alpha subunit, sodium channel protein skeletal muscle subunit alpha, sodium channel protein type IV subunit alpha, sodium channel, voltage-gated, type IV, alpha subunit, voltage-gated sodium channel subunit alpha Nav1.4

Genomic Location:

Chr 17: 59369646-59404010

Description:

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene fam...

View Full Description

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGTA_MIR524 ,  GGGYGTGNY_UNKNOWN ,  GAANYNYGACNY_UNKNOWN ,  CAGCTG_AP4_Q5 ,  AP4_Q5

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-378

Cytogenetic Map:

17q23.3

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