QuickView for SDC1 (gene)

Gene Symbol:

SDC1 Homo sapiens

Full name:

syndecan 1

Synonyms:

CD138, SDC, SYND1, syndecan, syndecan-1, CD138 antigen, heparan sulfate proteoglycan fibroblast growth factor receptor, syndecan proteoglycan 1

Genomic Location:

Chr 2: 20264039-20288675

Description:

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an inte...

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The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  PR_02 ,  TGGNNNNNNKCCAR_UNKNOWN ,  PR_01 ,  CACGTG_MYC_Q2 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  AMEF2_Q6 ,  GR_Q6_01 ,  GGGAGGRR_MAZ_Q6 ,  STAT3_02 ,  LEF1_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  AGCTCCT_MIR28 ,  GR_Q6 ,  AR_03 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  CTCTGGA_MIR520A_MIR525 ,  STAT_01 ,  MYB_Q6 ,  AP2_Q6 ,  GR_01 ,  WWTAAGGC_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  STAT1_01 ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  ER_Q6_01 ,  MMEF2_Q6 ,  CACBINDINGPROTEIN_Q6 ,  CDC5_01 ,  ACAGGGT_MIR10A_MIR10B ,  PAX2_02 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93

Cytogenetic Map:

2p24.1

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