QuickView for SDHB (gene)
- Gene Symbol:
- SDHB
Homo sapiens - Full name:
- succinate dehydrogenase complex iron sulfur subunit B
- Synonyms:
- CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, iron-sulfur subunit of complex II, succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- Genomic Location:
- Chr 1: 17217804-17253252
- Description:
-
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CREBP1CJUN_01 , ATF4_Q2 , MYCMAX_B , CREB_Q4 , TGACCTY_ERR1_Q2 , TGAYRTCA_ATF3_Q6 , CREBP1_Q2 , CREB_02 , ATF1_Q6 , CREB_Q2
- Cytogenetic Map:
-
1p36.13
GO Molecular Function
cofactor binding | succinate dehydrogenase activity | cation binding | catalytic activity | succinate dehydrogenase (ubiquinone) activity | electron transfer activity | iron-sulfur cluster binding | 3 iron, 4 sulfur cluster binding | ion binding | ubiquinone binding | protein binding | 2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | quinone binding | metal ion binding | oxidoreductase activity, acting on the CH-CH group of donors | oxidoreductase activity
GO Biological Process
succinate metabolic process | tricarboxylic acid cycle | generation of precursor metabolites and energy | aerobic respiration | cellular process | succinate dehydrogenase activity | dicarboxylic acid metabolic process | cellular respiration | electron transport chain | succinate dehydrogenase (ubiquinone) activity | antibiotic metabolic process | electron transfer activity | small molecule metabolic process | drug metabolic process | carboxylic acid metabolic process | tricarboxylic acid metabolic process | metabolic process | oxidation-reduction process | citrate metabolic process | organic substance metabolic process | organic acid metabolic process | energy derivation by oxidation of organic compounds | oxidoreductase activity, acting on the CH-CH group of donors | cellular metabolic process | oxidoreductase activity | respiratory electron transport chain
GO Cellular Component
organelle inner membrane | intracellular membrane-bounded organelle | catalytic complex | mitochondrial inner membrane | organelle membrane | cell | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | oxidoreductase complex | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | plasma membrane | mitochondrial respiratory chain | respiratory chain | mitochondrion | respiratory chain complex II | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | succinate dehydrogenase complex | cell periphery | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
