QuickView for SEPT7 (gene)

Gene Symbol:

SEPT7 Homo sapiens

Full name:

septin 7

Synonyms:

CDC10, CDC3, NBLA02942, SEPT7A, septin-7, CDC10 (cell division cycle 10, S. cerevisiae, homolog), CDC10 protein homolog, septin 7 variant 4

Genomic Location:

Chr 7: 35807152-35911442

Description:

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which...

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This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  NFMUE1_Q6 ,  TTTGCAC_MIR19A_MIR19B ,  CTCTATG_MIR368 ,  TMTCGCGANR_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  WGTTNNNNNAAA_UNKNOWN ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GGGAGGRR_MAZ_Q6 ,  GGATCCG_MIR127 ,  TGCAAAC_MIR452 ,  CACCCBINDINGFACTOR_Q6 ,  YY1_Q6 ,  CAGGTG_E12_Q6 ,  ATTCTTT_MIR186 ,  GTTTGTT_MIR495 ,  CTCTGGA_MIR520A_MIR525 ,  TCTATGA_MIR376A_MIR376B ,  TTGCCAA_MIR182 ,  AAAYRNCTG_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  YY1_02 ,  CCCNNNNNNAAGWT_UNKNOWN ,  TACAATC_MIR508 ,  TAANNYSGCG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  GGGTGGRR_PAX4_03 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-127 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-325 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

7p14.2

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