QuickView for SERPINC1 (gene)

Gene Symbol:

SERPINC1 Homo sapiens

Full name:

serpin family C member 1

Synonyms:

AT3, AT3D, ATIII, THPH7, antithrombin-III, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1

Genomic Location:

Chr 1: 172139565-172153096

Description:

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the...

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The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ARP1_01 ,  CTTTGA_LEF1_Q2 ,  COUP_01 ,  TGACCTY_ERR1_Q2 ,  LEF1_Q2 ,  PXR_Q2 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AACTTT_UNKNOWN ,  HNF4_01_B

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Cytogenetic Map:

1q25.1

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