QuickView for SESN1;jsessionid=59A04712DA58A6C5D6F796FFCDFDE964 (gene)

Gene Symbol:

SESN1 Homo sapiens

Full name:

sestrin 1

Synonyms:

PA26, SEST1, sestrin-1, p53 activated gene 26, p53 regulated PA26 nuclear protein

Genomic Location:

Chr 6: 109414338-109521970

Description:

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapa...

View Full Description

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGIF_01 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  GGGCGGR_SP1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CTGAGCC_MIR24 ,  TGACAGNY_MEIS1_01 ,  RCGCANGCGY_NRF1_Q6 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GGGTGGRR_PAX4_03

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-24

miRNA binding sites
(Source: miRecords):

hsa-miR-21 Targeted Genes

Cytogenetic Map:

6q21

search → result