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QuickView for SESN2;jsessionid=B4638F6AE94646C01E6F33D45364C2A4 (gene)


Gene Symbol:
SESN2 Homo sapiens Homo sapiens
Full name:
sestrin 2
Synonyms:
HI95, SES2, SEST2, sestrin-2, hypoxia induced gene 95, hypoxia-induced
Genomic Location:
Chr 1: 28458593-28481589
Description:
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1p35.3


Transcripts Names
NM_031459
XR_946773
Protein Names
Q96SI5
P58004
Q5T7D0



GO Molecular Function

leucine binding | cation binding | antioxidant activity | carboxylic acid binding | GTPase regulator activity | molecular function regulator | catalytic activity | anion binding | amino acid binding | oxidoreductase activity, acting on a sulfur group of donors | ion binding | protein binding | sulfiredoxin activity | GDP-dissociation inhibitor activity | enzyme regulator activity | organic acid binding | oxidoreductase activity, acting on peroxide as acceptor | oxidoreductase activity | small molecule binding

GO Biological Process

negative regulation of TOR signaling | response to extracellular stimulus | cellular response to glucose starvation | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to endoplasmic reticulum stress | regulation of response to oxidative stress | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of carbohydrate metabolic process | mitochondrial DNA metabolic process | establishment of localization | regulation of autophagy | response to hormone | negative regulation of translation in response to stress | negative regulation of cellular process | fatty acid beta-oxidation | cellular response to extracellular stimulus | reactive oxygen species metabolic process | glucose homeostasis | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | cellular detoxification | antioxidant activity | negative regulation of signaling | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress | response to leucine | cellular response to starvation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | cellular lipid metabolic process | response to stimulus | regulation of cellular protein localization | monocarboxylic acid metabolic process | GTPase regulator activity | carboxylic acid catabolic process | response to stress | monosaccharide transmembrane transport | positive regulation of cellular protein localization | posttranscriptional regulation of gene expression | negative regulation of translation in response to endoplasmic reticulum stress | response to peptide | response to glucose | response to starvation | fatty acid catabolic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | regulation of macroautophagy | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | mitochondrion organization | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | regulation of TOR signaling | molecular function regulator | regulation of nucleic acid-templated transcription | response to nitrogen compound | protein kinase B signaling | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | DNA damage response, signal transduction by p53 class mediator | negative regulation of growth | response to amino acid | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | cellular response to amino acid starvation | oxidoreductase activity, acting on a sulfur group of donors | signal transduction in response to DNA damage | regulation of gene expression | regulation of TORC1 signaling | organic substance transport | cellular response to stress | positive regulation of cellular metabolic process | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | small molecule metabolic process | hexose transmembrane transport | regulation of transcription by RNA polymerase II | response to oxidative stress | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | regulation of cAMP-dependent protein kinase activity | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | cellular response to leucine | triglyceride homeostasis | response to toxic substance | cellular response to amino acid stimulus | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | mitochondrial genome maintenance | cellular lipid catabolic process | regulation of protein metabolic process | lipid modification | homeostatic process | response to monosaccharide | regulation of protein phosphorylation | regulation of RNA metabolic process | carbohydrate transport | negative regulation of cell growth | carboxylic acid metabolic process | carbohydrate transmembrane transport | regulation of growth | response to organic substance | positive regulation of lipophagy | regulation of kinase activity | DNA metabolic process | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | response to insulin | sulfiredoxin activity | regulation of glucose metabolic process | metabolic process | regulation of DNA-templated transcription in response to stress | cellular oxidant detoxification | regulation of RNA biosynthetic process | oxidation-reduction process | glucose import | chemical homeostasis | nucleobase-containing compound metabolic process | lipid catabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | negative regulation of TORC1 signaling | negative regulation of translation | fatty acid metabolic process | positive regulation of autophagy | positive regulation of macroautophagy | lipid oxidation | glucose transmembrane transport | GDP-dissociation inhibitor activity | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | organic acid metabolic process | enzyme regulator activity | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of translation in response to stress | regulation of translation in response to endoplasmic reticulum stress | organelle organization | regulation of cell growth | acylglycerol homeostasis | positive regulation of transcription, DNA-templated | detoxification | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | response to amino acid starvation | regulation of gluconeogenesis | fatty acid oxidation | oxidoreductase activity, acting on peroxide as acceptor | positive regulation of metabolic process | cellular metabolic process | cellular response to leucine starvation | cellular response to organic substance | regulation of protein localization | response to carbohydrate | oxidoreductase activity | regulation of translation | signal transduction by p53 class mediator | carbohydrate homeostasis | lipid homeostasis | regulation of cellular component organization | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | protein kinase complex | cell | cytoplasm | intracellular organelle | Seh1-associated complex | GATOR2 complex | protein-containing complex | Atg1/ULK1 kinase complex | transferase complex | TORC2 complex | mitochondrion | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | nucleotide-activated protein kinase complex | cytosol | intracellular