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QuickView for SH2B1;jsessionid=C334B788719D2D1F44904F62090B5B24 (gene)


Gene Symbol:
SH2B1 Homo sapiens Homo sapiens
Full name:
SH2B adaptor protein 1
Synonyms:
PSM, SH2B, SH2B adapter protein 1, SH2 domain-containing protein 1B, SH2 domain-containing putative adapter SH2-B, SH2-B signaling protein, pro-rich, PH and SH2 domain-containing signaling mediator
Genomic Location:
Chr 16: 28782815-28793027
Description:
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 16
16p11.2





GO Molecular Function

kinase binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | transmembrane receptor protein tyrosine kinase adaptor activity | signaling receptor binding | signaling adaptor activity | protein binding, bridging | protein tyrosine kinase binding | molecular adaptor activity | protein binding

GO Biological Process

regulation of cell cycle process | positive regulation of cellular component organization | intracellular signal transduction | regulation of organelle organization | cellular process | regulation of mitotic nuclear division | hemostasis | regulation of cell cycle | regulation of cellular process | regulation of metabolic process | cellular component organization | response to stimulus | lamellipodium assembly | transmembrane receptor protein tyrosine kinase adaptor activity | response to stress | cellular component assembly | blood coagulation | signaling adaptor activity | regulation of signal transduction | positive regulation of organelle organization | wound healing | positive regulation of cell cycle | positive regulation of mitotic cell cycle | cell projection assembly | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | coagulation | regulation of mitotic cell cycle | lamellipodium organization | response to wounding | cell surface receptor signaling pathway | cell projection organization | regulation of body fluid levels | regulation of cell communication | signaling | regulation of DNA biosynthetic process | positive regulation of cell cycle process | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of cellular component organization | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane