QuickView for SIM1 (gene)

Gene Symbol:

SIM1 Homo sapiens

Full name:

single-minded family bHLH transcription factor 1

Synonyms:

bHLHe14, single-minded homolog 1, class E basic helix-loop-helix protein 14

Genomic Location:

Chr 6: 100943471-101018272

Description:

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a...

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SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  TAL1ALPHAE47_01 ,  FOX_Q2 ,  AAAYWAACM_HFH4_01 ,  HOXA3_01 ,  MEIS1BHOXA9_01 ,  IRF1_Q6 ,  TATAAA_TATA_01 ,  TAL1BETAE47_01 ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  TATA_C ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  TTGTTT_FOXO4_01 ,  MSX1_01 ,  TATA_01 ,  TAL1BETAITF2_01 ,  AACTTT_UNKNOWN ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-378

Cytogenetic Map:

6q16.3

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