QuickView for SIRPA;jsessionid=DDD3DFCE50DF38E173DB203273BF62E2 (gene)

Gene Symbol:

SIRPA Homo sapiens

Full name:

signal regulatory protein alpha

Synonyms:

BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, tyrosine-protein phosphatase non-receptor type substrate 1, CD172 antigen-like family member A, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, inhibitory receptor SHPS-1, macrophage fusion receptor, myd-1 antigen, tyrosine phosphatase SHP substrate 1

Genomic Location:

Chr 20: 1822813-1868540

Description:

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated...

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The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGTTGA_MIR505 ,  PU1_Q6 ,  CEBPA_01 ,  YTATTTTNR_MEF2_02 ,  CEBP_Q2_01 ,  WGTTNNNNNAAA_UNKNOWN ,  TGACCTY_ERR1_Q2 ,  WHN_B ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  AATGTGA_MIR23A_MIR23B ,  CEBP_Q3 ,  ELK1_01 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  CTGCAGY_UNKNOWN ,  ER_Q6_02 ,  ER_Q6_01 ,  ERR1_Q2

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

20p13

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