QuickView for SLC16A2 (gene)

Gene Symbol:

SLC16A2 Homo sapiens

Full name:

solute carrier family 16 member 2

Synonyms:

AHDS, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, MRX22, XPCT, monocarboxylate transporter 8, X-linked PEST-containing transporter, monocarboxylate transporter 7, solute carrier family 16, member 2 (thyroid hormone transporter)

Genomic Location:

Chr X: 73557810-73670475

Description:

This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of ...

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This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E2F1_Q4_01 ,  E2F_Q6_01 ,  GGGAGGRR_MAZ_Q6 ,  GGGCGGR_SP1_Q6 ,  TCCAGAT_MIR5165P ,  TGTTTGY_HNF3_Q6 ,  E2F_03 ,  E2F_Q4_01 ,  TCTCTCC_MIR185 ,  GGCAGCT_MIR22 ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CAGCCTC_MIR4855P ,  ETS1_B ,  TCATCTC_MIR143 ,  E2F_Q3_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

Xq13.2

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