QuickView for SLCO1B1 (gene)

Gene Symbol:

SLCO1B1 Homo sapiens

Full name:

solute carrier organic anion transporter family member 1B1

Synonyms:

HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1, OATP-2, liver-specific organic anion transporter 1, sodium-independent organic anion-transporting polypeptide 2, solute carrier family 21 (organic anion transporter), member 6

Genomic Location:

Chr 12: 21175404-21283997

Description:

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as...

View Full Description

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.

View Less

Orthologs:

Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF1_01 ,  TTANTCA_UNKNOWN ,  STAT5B_01 ,  STAT5A_01 ,  HNF1_Q6

Cytogenetic Map:

12p12.1

search → result