QuickView for SNIP1;jsessionid=1DF9FF693A3646A7755D579069C80678 (gene)

Gene Symbol:

SNIP1 Homo sapiens

Full name:

Smad nuclear interacting protein 1

Synonyms:

PML1, PMRED, smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, PML1 homolog

Genomic Location:

Chr 1: 37774729-37792490

Description:

This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stabi...

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This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  TTTGCAC_MIR19A_MIR19B ,  GCATTTG_MIR105 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTTTGTA_MIR524 ,  GCTCTTG_MIR335 ,  P53_02 ,  GGAANCGGAANY_UNKNOWN ,  TGCCTTA_MIR124A ,  ACCAAAG_MIR9 ,  ELK1_01 ,  SCGGAAGY_ELK1_02 ,  TGCACTT_MIR519C_MIR519B_MIR519A

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

1p34.3

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